Identifying the Membrane Proteome of HIV-1 Latently Infected Cells
نویسندگان
چکیده
منابع مشابه
Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules.
Anti-retroviral drugs suppress HIV-1 plasma viremia to undetectable levels; however, latent HIV-1 persists in reservoirs within HIV-1-infected patients. The silent provirus can be activated through the use of drugs, including protein kinase C activators and histone deacetylase inhibitors. This "shock" approach is then followed by "kill" of the producing cells either through direct HIV-1-induced...
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Combination antiretroviral therapy (cART) has transformed the outcome of human immunodeficiency virus-1 (HIV-1) infection from a severe immunodeficiency syndrome to a chronic clinically manageable disease. However, patients require lifelong therapy and are at risk of developing nonAIDS complications (1, 2). Despite viral suppression in patients on cART, HIV-1 persists via the establishment of a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m606324200